Entry information : MtuCP01_CNFD04045
Entry ID 3599
Creation 2006-08-23 (Filippo Passardi)
Last sequence changes 2006-08-23 (Filippo Passardi)
Sequence status complete
Reviewer Christophe Dunand
Last annotation changes 2006-08-23 (Christophe Dunand)
Peroxidase information: MtuCP01_CNFD04045
Name MtuCP01_CNFD04045
Class Catalase peroxidase    [Orthogroup: CP001]
Taxonomy Bacteria Actinobacteria Actinobacteria (class) Mycobacteriaceae Mycobacterium
Organism Mycobacterium tuberculosis    [TaxId: 1773 ]
Cellular localisation N/D
Tissue type N/D
Inducer N/D
Repressor N/D
Best BLASTp hits
Perox score E-value MtuCP01_CNFD04045
S start..stop
MboCP01_AF2122/97 1499 0 1..761 1..740
MtuCP01_CNFD04001 1498 0 1..761 1..740
MtuCP01_CNFD04007 1497 0 1..761 1..740
MtuCP01_H37rv 1496 0 1..761 1..740
Literature and cross-references MtuCP01_CNFD04045
Literature Zhang,M., Yue,J., Yang,Y.P., Zhang,H.M., Lei,J.Q., Jin,R.L.,
Zhang,X.L. and Wang,H.H.

Detection of Mutations Associated with Isoniazid Resistance in
Mycobacterium tuberculosis Isolates from China

J. Clin. Microbiol. 43 (11), 5477-5482 (2005)
DNA sequence http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=nucleotide&cmd=search&term=DQ056360&doptcmdl=GenBank
Protein ref. UniProtKB:   Q4TUW2
DNA ref. GenBank:   66737295
Protein sequence: MtuCP01_CNFD04045
Sequence Properties
first value : protein
second value (mature protein)
Length (aa):   %s   761 (303)
PWM (Da):   %s   82788.37 (32807.5)  
PI (pH):   %s   4.77 (9.17) Peptide Signal:   %s   cut: 28 range:28-330
Send to BLAST
Send to Peroxiscan
*.........1 .........2 .........3 .........4 .........5 .........6 .........7 .........8 .........9 .........0 .........1 .........2

Retrieve as FASTA  
Remarks Complete sequence from genomic. Probable sequencing error: extra cytidine (gcacccctg --> gcaccctg) was removed just after "LRKVIRT" (not "LRKVIRM"!), otherwise a frameshift occurs and the rest of the sequence has not homology with a CP. The authors of the sequencing mention (p.5481) that there is no frameshift in this CP, although (!) the NCBI accession includes this frameshift and shows a truncated form.
Note the unusual insertion of a quite large fragment: "LRKVIRMQPQVGWEVNDPDGD". (DNA: TGCAGCCACAAGTCGGGTGGGAGGTCAACGACCCC
GACGGGGATCTGCGCAAGGTCATTCGCAC). Interestingly, an insertion (4bp) was also seen at the same site in MtuCP01_C18.