View Redoxidase 3601

Entry information : HsGPx02 (GSHPx-2 / GPx-2)

Entry ID	3601
Creation	2007-01-04 (Marcia Pinheiro Margis)
Last sequence changes	2010-11-23 (Myriam Duval)
Sequence status	complete
Reviewer	Harold DuruflÃ©
Last annotation changes	2016-06-28 (Harold DuruflÃ©)

Peroxidase information: HsGPx02 (GSHPx-2 / GPx-2)

Name (synonym)

HsGPx02 (GSHPx-2 / GPx-2)

Class

Animal glutathione peroxidase [Orthogroup: Gpx1004]

Taxonomy

Eukaryota Metazoa Chordata Mammalia Hominidae Homo

Organism

Homo sapiens (human) [TaxId: 9606 ]

Cellular localisation

Cytosolic

Tissue type

N/D

Inducer

N/D

Repressor

N/D

Best BLASTp hits

Perox	score	E-value	HsGPx02 start..stop	S start..stop
PtroGPx02	395	1.91e-143	1..190	1..190
HlGPx02	395	1.91e-143	1..190	1..190
PpyGPx02	393	1.18e-142	1..190	1..190
MfGPx02	390	1.43e-141	1..190	1..190

Gene structure Fichier

Exons►

Exon	Start..End	Size	Exon	Start..End	Size	Exon	Start..End	Size	Exon	Start..End	Size
N° 1	65409223..65409444	220	N° 2	65406209..65406556	346
complement(join(65406209..65406556,65409223..65409444))

Literature and cross-references HsGPx02 (GSHPx-2 / GPx-2)

Literature	REFERENCE 1 Sukenaga Y., Ishida K., Takeda T., Takagi K. cDNA sequence coding for human glutathione peroxidase. Nucleic Acids Res. 15:7178-7178(1987). REFERENCE 2 Ishida K., Morino T., Takagi K., Sukenaga Y. Nucleotide sequence of a human gene for glutathione peroxidase. Nucleic Acids Res. 15:10051-10051(1987). REFERENCE 3 Mullenbach G.T., Tabrizi A., Irvine B.D., Bell G.I., Hallewell R.A. Sequence of a cDNA coding for human glutathione peroxidase confirms TGA encodes active site selenocysteine. Nucleic Acids Res. 15:5484-5484(1987). REFERENCE 4 Chada S., le Beau M.M., Casey L., Newburger P.E. Isolation and chromosomal localization of the human glutathione peroxidase gene. Genomics 6:268-271(1990).
Protein ref.	UniProtKB: P18283
Cluster/Prediction ref.	Genebank: 2877 UniGene: Hs.2704

Protein sequence: HsGPx02 (GSHPx-2 / GPx-2)

Sequence Properties
first value : protein
second value (mature protein)

Length (aa):	190
PWM (Da):	21677.08
PI (pH):	7.93

Sequence
Send to BLAST
Send to Peroxiscan

.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0.........1.........2

MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLK
DKLPYPYDDPFSLMTDPKLIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI

Retrieve as FASTA

Remarks

Complete sequence from 347 ESTs, 9 cDNA and DNA (chromo, 1 intron).

Promoter►
Send to BLAST
Send to cis Analysis

.........1 .........2 .........3 .........4 .........5 .........6 .........7 .........8 .........9 .........0 .........1 .........2

ATGTGAACTG CTCAACACAC AGATCTCCTA CTCCATCCAG TCCTGAGGAG CCTTAGGATG CAGCATGCCT TCAGGAGACA CTGCTGGACC TCAGCATTCC CTTGATATCA GTCCCCTTCA CTGCAGAGCC TTGCCTTTCC CCTCTGCCTG TTTCCTTTTC CTCTCCCAAC CCTCTGGTTG GTGATTCAAC TTGGGCTCCA AGACTTGGGT AAGCTCTGGG CCTTCACAGA ATGATGGCAC CTTCCTAAAC CCTCATGGGT GGTGTCTGAG AGGCGTGAAG GGCCTGGAGC CACTCTGCTA GAAGAGACCA ATAAAGGGCA GGTGTGGAAA CGGCCAGCCT GTGTGTGTGT TCTTTGACAG AGGGCGGAGG GAAGCTACAA ACTGCAGGTG GGATAGAGGA GCTGCTAGCA CACAAAGCTT TGGGAGGGGA GGATCTGACG GATCAAGGGA TGCCCTAATT ACTGACAGGA AAGCAAGCGC TGGCCAAGGT CTGCAGTGGC AGGTGCAGTT ACGGGAAATG TGAATTATAT TATTCCTTTA CAGCTCTTCT TCAGAACTGG GGAAAAAGAG AAAGTGATAA TGGGAGGTAG AGGAGGAAAA GACAATGAGC CCTTTGGTTG GGGATATTGG GAGGCTGTTA GGAGGATTAC AGTCAGGAAG CATCAATAGC ACTGTGGGTA CTGGGCCAAC TAGATCTGAC TTGTGCCTTG GGAAATTCCT GGGCAGTCAG CTTAGTTAAT GTTTACCAAT AGCAAGGGCA TAGAGGGTGT AGTTACTGAG AACACAAACA GCACTTTATC TTTTTCCTGA TCATCAAACA TCTCGGGTGT TTGATCCTTT GCTAGACTGA TTCTCCCTCC TTTTTAAAGT TCATGGCCCG GGTGTGGTGG CTCACACCTA TAATCCCAGC ACTTTGAGAG GCCGAGACAG GCGGATCACT TGAGGTCAGG AGTTCGAGAC CAGCCTGGCC AACATGATGA AACTCTGTCT GTACTAAAAA TACAAAAAAT TAGCCAGGTG TGGTGGCGCA CGCCTGTAAT CCCAGCTACT CAGGAGGCTG AGGTGAGAGA CTCATTTGAA CCCGGGAGGT GGAGGCTGCA GTGAGCCAAG ATGGCGGCGC CACTACACTC CAGCCTGGGC GACAGAGTGA GACTCCGTCT CAAAATAAAT AAATAAAGTT CACATTACAC CCTCATTCTT CTCAAAATCA CATATTCACA AATTCAGGCT CCAGACAAAT AGAGGCAGGA ATGACTGGAC TCATTTCTTC CTCTGTAAGA AGGAAGGGGT TGGGGATGGG AGAGAGCCTC CCTTCAGAGT CAGGCTGTTT ATAATCTGCC ATTTGCAACA TCATTATTCC TCACTGTGAG GACAGTTTTG CTCAGAGGCC TTGCAAGGAT GGTGTCCCCA ATTCCTCATC CAGTGCAGAC ATAATCAAAA CATATCACCA CCGCCAAGGT CAGGTTCTAT CATGTTCTGG AAAAGATACC TGCTGAGAGG CCACTGCCTG TCACCTTGCC CCACAGACCT CATCCTGGAA ACTTCTCATT TCATCTTCCC TTCTTTGACC ACTAGATGGA ATATTTTCAC TTCTATTCAC TGAAACCCTG AAGGGACAGT TTTCCAAACT GGACACACTG CTTGAGAAGC CCAATGCTGA AGGGAAAATG TTTTTCCTTT AATTGTTCTG CTTACCCTAA CCATTTTCTA AGCACTTGCA TCATATGAGA GTGAATGTGG AATAGATGTT TAGGATCCCC ACTTTCTGAC CTTCAACTAA ACCTGTCAAC AACAGTGCTT TATTTCAAAA GGGTAACCTG AGTATTACAG TGGGAATCCC CTGACACCTT TCTGCAGGGC CTTCTGCTAA CTTAAGGCTA CCCTTACCTT CACTCTTGAA ACCTCAAGCC TTTCAGATTC
CTGCTCTTAA AGTCAACAGC TGGGGTATGA ATTATTATGG GGCAGGACCA TGTACTGATT TTAGAGCAGT AACTGCAGAC

Retrieve as FASTA

Terminator +►
Send to BLAST
Send to cis Analysis

.........1 .........2 .........3 .........4 .........5 .........6 .........7 .........8 .........9 .........0 .........1 .........2

GCGTCTGGAA CCACAGCAGC TTCAACTTCC TCCACACACT TCCTTCTGTG GGAAGGTGAC CAGCACAAAC CCGCTCTGAA AAGTCTTGGG GACCAAATCT CTGTCTGAGA GGAAGGTAGG TGCAGTTCAT CCACTAAGTT TATCCACCTG TTCTGTGACT CCTCTTCACC ATTCTCCCAG CAACGACTGA GCCTCATGAC TTGGGGGCTG GGGGATGAGG TGGAGGTGGG GGATATAATA TAGGAGATGG TACAGTGCAG GGGCAGAGGC TGGTGTGTTC TCCAGGACAA GTGGCACCAC GCACTGAAAG ACTTTTCAAG ATAAACACAA CTTTGTCTCT TCAGCCTGGC AAGAGCTGAG GCACTGAAAA CTTCTTTTTT CCCCTAGAAA ATGACACACT CTCCTCCTAA GGGTCCCTTT GATTTTGTCC TGGTGGAAAG CAACAAAGAG AAGAACGTGA ACAGGAATAT GTATATTTCA GTTGTCATCT GAGTCCCATG GATAGGAGGC TCAATTCTCT TCTTCATCTT TCAGATCTCC GCAGACCCTG CCCTCTCACT GTACAATTCA GAGATTGACA CTCAGCAGGC ATTCAATAAA CGTCTGTGTC AAATGAGAAC AACTTGATGG GGCAAGTAGG AGTCAATCCT GCATCCCTCC CTCCCTTTTT TTCCTCTCCA TTCGACCTTT AGGGCTCTGG TTTCCTGTAA GCAGTGAATT ATTTACCTCT GCTCATAGAT ATCAAATTGG CCCTTCCCAG GTTGCAGCAG GGTGGGGCGG GGAGGCGGCC TTGTTCAGTC TGTTAATAGG AGGAGCAACC TCCTTGTTCA AACAGCACTT ACAGGTGGGG ACCTGTTTTT GCTAAGTCAT CCTGGGGATG CTCAAAGCTC CATTGTTAGA TCCTTTCTGT CCTCCTTCCT GGCTCCTCCT TCCTCCCCAC CCCTCTAATA GGCTCATAAG
TGGGCTCAGG CCTCTCTGCG GGGCTCACTC TGCGCTTCAC

Retrieve as FASTA

DNA ►
Send to BLAST

.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0.........1.........2

ATGGCTTTCATTGCCAAGTCCTTCTATGACCTCAGTGCCATCAGCCTGGATGGGGAGAAGGTAGATTTCAATACGTTCCGGGGCAGGGCCGTGCTGATTGAGAATGTGGCTTCGCTCTGA
GGCACAACCACCCGGGACTTCACCCAGCTCAACGAGCTGCAATGCCGCTTTCCCAGGCGCCTGGTGGTCCTTGGCTTCCCTTGCAACCAATTTGGACATCAGGTGAGGGGTCCCTCCTTG
TAATGCACCAAAAGTGTTGGGTTGGTGTAGCTCAGGTGGGATAAAAGGAGAGGCTGAATGACCATGTTTTGGAGTGTCTGGAATAATGGGGTATGTTTTGTTAAGCTAGGTCTTTAGGTG
CATGTGACATACCAAGAGAAGGTATATATTTTTTAAGATTAAACACTGAGGCTGTGTGATTTTTATAGTTTACTGTCTTTCTACTATATTACTCCATGAGGGCTGGTTCCAGGTCTGTGT
TTCTCTCCACTGTGTCCTCAGTGCCTAGGGCACAGAAAGCACTCATTAAATATTTGTTGAATAAATGAGTGGAGAAAGTAGAGGCCAGGAATCAAACAAGAATTGGACAGACTCAAGAGA
CCTTAGCTCTAGCTGGACTTGGTTTTGCTATTTAATGGCTCTGTGCCCTCGGAAAGGGCGCTTCATTTTTCGGTTTAGTTTCCTCATCTGTAAATTGGGGATAATACCACTTAGCTCATA
GGATTATTATGATGTTTAGGGGACAGGATATACAAAAGTAACTTGAAAAATATAAAGTACTATGCAAATGCAAGCAAACTGTTATTTAGATTGAGGATGATTTTTGTTGGTTTAAATTAG
CCAAGTGGAAAGAAAATAAGCAGGAAAGAGAAAGGTTTTCAAAAGGCACGTGCCTCTGGGCATTACATGCACCTATTTCTGATTAATGGGTCAAGCTGTTATAGATCTTCAGCCCACACA
CCTCGAGTTCTCTTTTAGGGATTCTTCTATTTCCACCTATGATTTTAACGTACAAGCAGGGAGAATGAACCCAAGCGAACCCTCTCGTTATAATCCCCTTAGTTCAATTCACAGTGGTAT
GAAGGTGAGGAAGACAGGAAAGCAGGAAGGCTGAAGCATCACTGGCTGTGACAAACCTGAGCCCAAACTGTTCACTGCTCTCACTGTTCTTCCCTAAGTTTTCTGTCTGGCCTTTTCTAG
AGCAGGAGAGACAGAAGTAGCAAACCCTCTTTCGAGATGTCCCTCCAGCCCCAGAAGTACCTCCAGCCTCACACCATCTCTTCAGCCTAGCAAGTTGCTGGAGGGAGTCTATAACCTACC
AGGAGCCAGCCAGCCATTTGTATCAAGAAATAGAAATCTGCCAGGGTACAGTGGCTCACACCTATAATCCCAGCGCTTTGGGAGGCTAAGGTAGGCAGATTGCTTGAGCTCAGGAGTTCA
AGATTAGCCTGAGCAACATGGTGAAACCTTGTTTCTACAAAAAATTGCAAAAATTAGCCAGGCATGGTGGCATGTGCCTGTAGTCACAGCTACTTGGGACGCTGAAGTAGCAGGATCGCC
TGAGCCTGGGAAGTCGAGGCTGCAGTGAGCTATGATTGTGCCACCGCACCCCAGCCTAGGTGACAGAGTGAGGCCCTGTCTCAGGAAAAAAAACAGAAACAAAAACAGAGAAGTCCACTA
GAGATCAGCTCTGGGCTCATGATGTCATGATGGCCTGGAACTGACTGAACTAGTTAGTTCTCACAGGTCAGAAGCAGGAACTTTCTCCCAGAGGAAGGTATCTGTCTGTTAAATTGGAAA
GGTAGAGGTGGAAAAGAAGGGTTCCCATAGGCCTTTTGGATTGTCATGAATGGTGATGCTGAGAGGGAATAGGACAGGGATGGCAGTGGGGAGGGAAAGGCAGGGACCAGGTTTTGAGCC
AAAGCATGCGTAGCTGAGAGCAGTGAGTGGATAGGAGGTGCAGCAGTCTTTGGGTAGCAGCCTACTCAAGAAAAGAATGATAATTACATACTCACAATCTTTAGCCATCAAGCACTTATT
TCCTCAACTCCCCCTCCCCCTGGCCTATTGCCAAACCCTAAATCCTGTATCCTATTTACTTCATGCCTGTTGGTTACTAAGTAGTTCCATTTAGAGTACACATTCATTGTTGCCTTGAAC
TTGCTCTGCTGTTATGGCACCTGAAAACTAGATGTTCTTGGATGGGGGTCTTCCTTCATCAAAGCTTCTTCCCATTTGTACTTCAGTTCTAGGACAAGGCAAGAAGAAAGCAAGAAGCTG
TAAATCCCATTCCTCTGGGTCTCAATTTCACCCTCAGTTCAAGGAGCTGAGTAGGCAGAGGCAAAGGCTATACTCAACACACGTGCAATTGAAAGCAGGCGAGGCAAAACCAGGGCAGAG
GAAAGGAAAGGGGTGTGTGTGTAGGTATGGATTTATGGGTAGGTGGGTCGGTAGGTTAGTTGAAGAGGAGGTTCTAAGCAGTATAACCTAAGCCTCTTTTCTCTTTCTTCTGCTTCAAAC
ACCTTAAGAACTGCTCAGGGTAGACTGGAGACAAAAGCAACAGCTCAGAAGTGCTAAATCTTGAAGAGCAGCCAAAGCATGGGCAACAAAGTGAGACCCCATCTCTACAAAAAAAAAAAA
AAATTAGCCGGGCATGGTGGCCTGTGTCTGTAGTCTCAGCTACTAAAGAGGCTGAAGCAGGAGGAATGCTTGAGCCCAGAAGTTCAAGGCTGCAGTGAGCAACACCTCGTCTGTCTTGTC
TCTCTCTCTTTCACAGTGAAAAAGAATGACCCTGGGGAGGGAGTGTAGGAGGGTGAAAGAGTTTCATGTTGTGGATCTTTCTCTTCCCCCACCCACTGTCCACGCACTTTGTCTTTTTCC
TCCCCTAGGAGAGAACTGTCAGAATGAGGAGATCCTGAACAGTCTCAAGTATGTCCGTCCTGGGGGTGGATACCAGCCCACCTTCACCCTTGTCCAAAAATGTGAGGTGAATGGGCAGAA
CGAGCATCCTGTCTTCGCCTACCTGAAGGACAAGCTCCCCTACCCTTATGATGACCCATTTTCCCTCATGACCGATCCCAAGCTCATCATTTGGAGCCCTGTGCGCCGCTCAGATGTGGC
CTGGAACTTTGAGAAGTTCCTCATAGGGCCGGAGGGAGAGCCCTTCCGACGCTACAGCCGCACCTTCCCAACCATCAACATTGAGCCTGACATCAAGCGCCTCCTTAAAGTTGCCATA

Retrieve as FASTA

CDS►
Send to BLAST

.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0.........1.........2

Retrieve as FASTA