Ferritin family

Contact author:
Last update: 2021-12-02 (Bruno Savelli)

Ferritin family (Fer)


Ferritin is one of the major non-haem iron storage proteins in animals, plants, and microorganisms [15222465]. It consists of a mineral core of hydrated ferric oxide, and a multi-subunit protein shell that encloses the former and assures its solubility in an aqueous environment. In animals the protein is mainly cytoplasmic and there are generally two or more genes that encode closely related subunits - in mammals there are two subunits which are known as H(eavy) and L(ight). In plants ferritin is found in the chloroplast


Ferritin-like domain :
Pfam: PF00210
Ferritin-like domain; PF13668 Ferritin_2; PF12902 Ferritin-like
Interpro: IPR008331
Ferritin/DPS protein domain


Andrews SC. The Ferritin-like superfamily: Evolution of the biological iron storeman from a rubrerythrin-like ancestor. Biochim Biophys Acta. 2010 Aug;1800(8):691-705. PMID: 20553812.
Bai L, Xie T, Hu Q, Deng C, Zheng R, Chen W. Genome-wide comparison of ferritin family from Archaea, Bacteria, Eukarya, and Viruses: its distribution, characteristic motif, and phylogenetic relationship. Naturwissenschaften. 2015 Oct;102(9-10):64. PMID:26411976.
Stiefel EI, Grossman MJ, Hinton SM, Minak-Bernero V, George GN, Prince RC, Bare RE, Watt GD. Bacterioferritin: a hemoprotein member of the ferritin family. Adv Exp Med Biol. 1994;356:157-64. PMID:7887220.
Lee JH, Wan KL, Mohd-Adnan A, Gabaldón T. Evolution of the ferritin family in vertebrates. Trends in Evolutionary Biology 4, 1 (2012)