Entry information : HsMPO
| Entry ID | 3315 |
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| Creation | 2006-07-14 (Christophe Dunand) |
| Last sequence changes | 2006-07-14 (Christophe Dunand) |
| Sequence status | complete |
| Reviewer | Filippo Passardi |
| Last annotation changes | 2010-12-03 (Myriam Duval (Scipio)) |
Peroxidase information: HsMPO
| Name | HsMPO | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Class | Myeloperoxidase [Orthogroup: MPO001] | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Taxonomy | Eukaryota Metazoa Chordata Mammalia Hominidae Homo | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Organism | Homo sapiens (human) [TaxId: 9606 ] | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cellular localisation | Cytosolic |
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| Tissue type | Hemocyte |
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| Inducer | N/D |
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| Repressor | N/D |
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| Best BLASTp hits |
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| Gene structure Fichierperl './assets/cgi-bin/draw_exon.pl' '3315' 'complement(join(56348017..56348224,56349016..56349253,56350109..56350279,56350775..56351030,56352903..56353063,56355188..56355506,56356369..56356575,56356658..56356787,56356884..56357007,56357200..56357375,56357727..56357820,56357966..56358119))' |
Exons►
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Literature and cross-references HsMPO
| Literature | Morishita K., Kubota N., Asano S., Kaziro Y., Nagata S. Molecular cloning and characterization of cDNA for human myeloperoxidase. J. Biol. Chem. 262:3844-3851(1987).
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| Protein ref. | UniProtKB: P05164 |
| DNA ref. | GenBank: NC_000017.1 (56358119..56348017) |
| mRNA ref. | GenBank: BC130476 (52..2286) |
| Cluster/Prediction ref. | Genebank: 4353 UniGene: Hs.458272 |
Protein sequence: HsMPO
| Sequence Properties first value : protein second value (mature protein) |
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| Sequence Send to BLAST Send to Peroxiscan |
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| Remarks | Complete sequence from genomic (chromo 17, 11 introns) and 437 ESTs. Localisation: in the primary granules of human neutrophils and monocytes (Hope et al., 2000). In lesser extent in monocytes and disappears upon the differentiation of monocytes into macrophages (Klebanoff 1991). Is cleaved into light chain and heavy chain. Signal peptide pos. 1-48, propetide pos. 49-164, light chain pos. 165-278, heavy chain pos. 279-745. |
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| DNA ► Send to BLAST |
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| CDS► Send to BLAST |
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